jiangzm（郭晓奎的个人作品）
本文目录郭晓奎的个人作品左建平的代表论著郭晓奎的个人作品 郭晓奎（主编）病原生物学-医学微生物学 科学出版社 2012郭晓奎（主编）病原生物学-医学寄生虫学 科学出版社 2012郭晓奎（主审）医学微生物学实验教程 人民卫生出版社 2011郭晓奎（主编）医学微生物学实验技术 人民卫生出版社 2010郭晓奎(主编) 感染与优生优育 第二军医大学出版社 上海 2009郭晓奎（主编）病原生物学教育教学 第二军医大学出版社 上海 2008郭晓奎（主编）病原生物学纲要（英文版） 科学出版社 2008郭晓奎（主编）病原生物学 科学出版社 2007郭晓奎(主编) 细胞微生物学 第二军医大学出版社 上海 2004郭晓奎(主编) 克隆识别 北京医科大学和中国协和大学联合出版社 北京1994 Zhang ZY, Sun ZQ, Wang ZL, Hu HR, Wen ZL, Song YZ, Zhao JW, Wang HH, Guo XK*, Zhang SL. Identification and pathogenicity analysis of a novel non-tuberculous mycobacterium clinical isolate with nine-antibiotic resistance.Clin Microbiol Infect.2013; 19(1):91-6. Zhang SM,Qiu J,Tian F,Guo XK,Zhang FQ,Huang QFCorrosion behavior of pure titanium in the presence of Actinomyces naeslundii.J Mater Sci Mater Med.2013 Feb 21. [Epub ahead of print] Zelin Cui, Yuhua Zhou, Hong Li, Yan Zhang, Shenjie Tang, Xiaokui Guo. Complex sputum microbial composition in patients with pulmonary tuberculosis. BMC microbiology. 2012, 12:276 Zelin Cui, WenbinShen, Zheng Wang, Haotian Zhang, Rao Me, Yanchun Wang, LingbingZeng, Yongzhang Zhu, Jinhong Qin, Ping He, and Xiao-Kui Guo*. Complete Genome Sequence of Klebsiellapneumoniae phage JD001. Journal of Virology. 2012, 86(24):13843. Zelin Cui, Zhen Song, Yanchun Wang, LingbingZeng, WenbinShen, Zheng Wang, Qingtian Li, Ping He, Jinhong Qin, and Xiao-Kui Guo*. Complete Genome Sequence of wide host-range Staphylococcus aureus phage JD007. Journal of Virology. 2012, 86(24):13880. Zhou Y, Tao J, Yu H, Ni JJ, Zeng LB, Teng QH, Kim K, Zhao GP, Guo XK*, and Yao YF. Hcp-family proteins secreted via type VI secretion system coordinately regulate Escherichia coli K1 interaction with human brain microvascular endothelial cells. Infection and Immunity, 2012 , 80(3):1243-51 Zhang ZY, Liu C, Zhu YZ, Wei YX, Tian F, Zhao GP, Guo XK*. Safety assessment of Lactobacillus plantarumJDM1 based on the complete genome. Int J Food Microbiol. 2012 Feb 1;153(1-2):166-70. Epub 2011 Nov 12. Wei YX, Zhang ZY, Liu C, Malakar PK, Guo XK*.Safety assessment of Bifidobacterium longum JDM301 based on complete genome sequences.World J Gastroenterol. 2012 Feb 7;18(5):479-88. Zhang MM, Zhao JW, Sun ZQ, Liu J, Guo XK, Liu WD, Zhang SL. Identification of RD5-encoded Mycobacterium tuberculosis proteins as B-cell antigens used for serodiagnosis of tuberculosis. Clin Dev Immunol. 2012; 2012:738043. Zhang Y, Lou XL, Yang HL, Guo XK, Zhang XY, He P, Jiang XC. Establishment of a leptospirosis model in guinea pigs using an epicutaneous inoculations route.BMC Infect Dis. 2012 Jan 25;12:20. Li QT, Huang JW, Guo HX, Guo XK, Zhu YZ, Dong K. Bactericidal activity against meticillin-resistant Staphylococcus aureus of a novel eukaryotic therapeutic recombinant antimicrobialpeptide.IntJ Antimicrob Agents, 2012, 39 (6):496-499. Peng N, Zhong Y, Zhang Q, Zheng M, Zhao W, Jiang H, Yang C, Guo X, Zhao G.Characterization of acetyl-CoA and propionyl-CoA carboxylases encoded by Leptospira interrogans serovar Lai: an initial biochemical study for leptospiral gluconeogenesis via anapleroticCO(2) assimilation. Acta Biochim Biophys Sin. 2012;44(8):692-702. Shi, Si-feng, Jia, Jing-fu, Guo, Xiao-kui, Zhao, Ya-ping, Liu, Bo-yu, Chen, De-sheng, Guo, Yong-yuan, Zhang, Xian-long. Toxicity of iron oxide nanoparticles against osteoblasts. JOURNAL OF NANOPARTICLE RESEARCH 2012; 14(9),1091, Zheng LL, Li YX, Ding J, Guo XK, Feng KY, Wang YJ, Hu LL, Cai YD, Hao P, Chou KC. A comparison of computational methods for identifying virulence factors. PLoS One. 2012; 7(8):e42517. Shi SF, Jia JF, Guo XK, Zhao YP, Chen DS, Guo YY, Cheng T, Zhang XL.Biocompatibility of chitosan-coated iron oxide nanoparticles with osteoblast cells.Int J Nanomedicine. 2012; 7:5593-602. Li QT, Zhu YZ, Dong K, Liu C, Zhou YH, Ni YX, Guo XK*. A novel sequence-based coa genotyping method to discriminate nosocomial ethicillin-resistant Staphylococcus aureus isolates. Ir J Med Sci. 2011, 180 (2): 463-8. Zhong Y, Chang X, Cao XJ, Zhang Y, Zheng H, Zhu Y, Cai C, Cui Z, Zhang Y, Li YY, Jiang XG, Zhao GP, Wang S, Li Y, Zeng R, Li X, Guo XK*. Comparative proteogenomic analysis of the Leptospira interrogans virulence-attenuated strain IPAV against the pathogenic strain 56601. Cell Res. 2011, 21 (8): 1210-29. Zhao JW, Sun ZQ, Zhang CZ, Yang HG, Yu XL, Wen ZL, Gao YF, Guo XK, Qi YM, Zhang SL. Cloning, expression and immunological evaluation of a short fragment from Rv3391 of Mycobacterium tuberculosis . Ann Microbiol. 2011, 61 (2): 345-353 Zhang ZY, Sun ZQ, Wang ZL, Wen ZL, Sun QW, Zhu ZQ, Song YZ, Zhao JW, Wang HH, Zhang SL, Guo XK*. Complete genome of a novel clinical isolated non-tuberculous mycobacterium strain JDM601.J Bacteriol. 2011, 193 (16): 4300-1. Zhang SM, Tian F, Huang QF, Zhao YF, Guo XK, Zhang FQ. Bacterial diversity of subgingival plaque in 6 healthy Chinese individuals.Exp Ther Med.2011; 2(5):1023-1029. Zhang Q, Zhang Y, Zhong Y, Ma J, Peng N, Cao X, Yang C, Zeng R, Guo X, Zhao G. Leptospira interrogans encodes an ROK family glucokinase involved in a cryptic glucose utilization pathway. Acta Biochim Biophys Sin . 2011, 43 (8): 618-29. Ning R, Zhang X, Guo X, Li Q. Staphylococcus aureus regulates secretion of interleukin-6 and monocyte chemoattractant protein-1 through activation of nuclear factor kappaB signaling pathway in human osteoblasts. Braz J Infect Dis. 2011, 15 (3): 189-94. Ning R, Zhang X, Guo X, Li Q. Attachment of Staphylococcus aureus is required for activation of nuclear factor kappa B in human osteoblasts. Acta Biochim Biophys Sin. 2010, 42(12): 883-92. Zhu YZ, Cai CS, Zhang W, Guo HX, Zhang JP, Ji YY, Ma GY,Wu JL, Li QT, Lu CP, Guo XK*. Immunoproteomic analysis of human serological antibodyresponses to vaccination with whole-cell pertussis vaccine (WCV). PLoS One. 2010; 5(11):e13915. YuhuaZhou, Ping Lin, Qingtian Li, Lizhong Han, HuajunZheng, Yanxia Wei, Zelin Cui, Yuxing Ni, XiaokuiGuo*. Analysis of the microbiota of sputum samples from patients with lower respiratory tract infections. Acta Biochim Biophys Sin. 2010;42(10):754-761. Wu,Chenyun; Fen, Yan; Qian, Gaochao; Wu, Jianhua; Luo, Jun; Wang, Ying; Chen,Guangjie; Guo, Xiaokui*; Wang, Zhaojun*. α-galactosylceramide protects mice from lethal coxsackie virus B3 infection and subsequent myocarditis. Clin Exp Immunol. 2010, 162(1):178-187. Wei YX, Zhang ZY, Liu C, Zhu YZ, Zhu YQ, Zheng H, ZhaoGP, Wang S, Guo XK*.Complete genome sequence of Bifidobacterium longum JDM301. J Bacteriol. 2010; 192(15):4076-7. Qingtian Li,Yuhua Zhou ,Ke Dong ,Xiaokui Guo*. Potential therapeuticefficacy of a bactericidal–immunomodulatory fusion peptide againstmethicillin-resistant Staphylococcus aureus skin infection. 2010. Appl Microbiol Biotechnol . 2010, 86:305–309. Cai CS, Zhu YZ, Zhong Y, Xin XF, Jiang XG, Lou XL, He P,Qin JH, Zhao GP, Wang SY, Guo XK*.Development of O-antigen gene cluster-specific PCRs forrapid typing six epidemic serogroups of Leptospira in China. BMC Microbiol. 2010; 10:67. Liu C, Zhang ZY, Dong K, Guo XK. Adhesion and immunomodulatory effects of Bifidobacte riumlactis HN019 on intestinal epithelial cells INT-407. World J Gastroentero.2010; 16(18):2283-90. Ke Dong, Qingtian Li, Chang Liu, Yunyi Zhang, Guoping Zhao, and Xiaokui Guo. Cloning and characterization of three cheB genes in Leptospira interrogans. Acta Biochim Biophys Sin . 2010, 42 (3): 216-223. Yang J,Xu J, Chen X, Zhang Y, Jiang X, XiaokuiGuo, and Guoping Zhao. Decrease of Plasma Platelet-Activating Factor Acetylhydrolase Activity inLipopolysaccharide Induced Mongolian Gerbil Sepsis Model. PLoS ONE 2010, 5(2): e9190. Cao XJ, Dai J, Xu H, Nie S, Chang X, Hu BY, Sheng QH,Wang LS, Ning ZB, Li YX, Guo XK, Zhao GP, Zeng R. High-coverage proteome analysis reveals the first insight of protein modification systems in the pathogenic spirochete Leptospira interrogans. Cell Res. 2010; 20(2):197-210. Lin W, Yang HL, Yang Y, Hu BY, Tan LZ, Guo XK. Cloning, expression, and immunologicalevaluation of a novel protein belonging to OmpA family in Leptospira interrogans Recent Works on Microbes andInfections in China, World Scientific Publishing Co. Pte. Ltd. , 2009.P1-12 Jiang,XG, Zhang XY, Zhong WJ, Nie YX, Yin WW, Li XW, Guo XK Surveillance of Leptospirosis and the MurineReservoirs in China 2005 Recent Works on Microbes and Infections in China,World Scientific Publishing Co. Pte. Ltd, 2009. P13-19. Yao Y,Xie Y, Perace D, Zhong Y, Lu J, Tao J,Guo XK, Kim KS.The type IIIsecretion system is involved in the invasion and intracellular survival ofEscherichia coli K1 in humanbrainmicrovascular endothelial cells.FEMS Microbiol Lett. 2009, 300(1):18-24. JianpingYuan, Ping Li, Jing Tao, Xiaodong Shi, Baoyu Hu, Huabiao Chen and XiaokuiGuo* H.pylori Escape Host Immunoreaction Through Inhibiting ILKExpressionByVacA.Cellular & Molecular Immunology, 2009, 6(3): 191-197. Zhang ZY, Liu C, Zhu YZ, Zhong Y, Zhu YQ, Zheng HJ, ZhaoGP, Wang SY, Guo XK. Complete genome sequence of Lactobacillus plantarum JDM1.J Bacteriol. 2009Aug;191(15):5020-5021. Zhang SM, Tian F, Jiang XQ, Li J, Xu C, Guo XK, Zhang FQ.Evidence for calcifying nanoparticles in gingivalcrevicular fluid and dental calculus in periodontitis. J Periodontol. 2009; 80(9):1462-70. TianF,Yu Y, Chen B, Li HR, Yao YF, Guo XK*. Bacterial, archaeal and eukaryotic diversity in Arctic sediment as revealed by16S rRNA and 18S rRNA gene clone libraries analysis. Polar Biology, 2009, 32(1):93-103. Zhao W, Chen CY, Zhang XY, Lai WQ, Hu BY, Zhao GP, QinJH, Guo XK*. Molecular characterization of the pL40 protein inLeptospirainterrogans. Can J Microbiol. 2009; 55(6):739-749. FengCY, Li QT, Zhang XY, Dong K, Hu BY,GuoXK. Immune strategies on single component LipL32 and multi-components recombinant LipL32-41-OmpL1 vaccines against Leptospira. Brazilian Journal of Medical and BiologicalResearch. 2009, 42(9):796-803 Liu C, Zhang ZY, Dong K, Yuan JP, Guo XK*.Antibiotic resistance of probiotic strains of lactic acidbacteria isolated from marketed foods and drugs. Biomed Environ Sci. 2009; 22(5):401-412. Qin Lu,De-Hong Yu, Chao Fang, Fang Liu, Xun Ye, Yi Zhao, Jie Qin, Xiao-KuiGuo, Min Liang, Fang Hu and Hong-zhuan Chen. Influence of E3 region on conditionally replicative adenovirus mediated cytotoxicity in hepatocellular carcinoma cells. Cancer biology and therapy, 2009, 8(12): 1127-1134. Yang RF,Guo XK, Yang J, Jiang YQ, Pang B,Chen C, Yao YF, Qin JH, Li QT. Genomic research for important pathogenic bacteria in China. Science in China Series C: Life Sciences, 2009, 52(1):50-63. JunweiYang, Yixuan Zhang, Jing Xu, Yan Geng, Xiaoying Chen, Hongling Yang, ShengnanWang, Hengan Wang,Xucheng Jiang, XiaokuiGuo, Guoping Zhao. Serum activity of platelet-activating factoracetylhydrolase is a potential clinical marker for leptospirosis pulmonaryhemorrhage.PloS ONE. 2009 4(1): e4181. Zhu YZ, Li QT, Wang L, Zhong Y, Ding GH, Li G, JiaPL,Shi TL, Guo XK*. Gene expression profiling-based in silico approach toidentify potential vaccine candidates and drug targets against B. pertussis and B. parapertussis.OMICS. 2008 ;12(3):161-169. Qin JH, Zhang Q, Zhang ZM, Zhong Y, Yang Y, Hu BY, ZhaoGP, Guo XK*. Identification of a novel prophage-like gene cluster actively expressed in both virulent and avirulent strains of Leptospira interrogans serovar Lai. Infect Immun. 2008; 76(6):2411-2419. Zhang YX, Geng Y, Yang JW, Guo XK, Zhao GP. Cytotoxic activity and probable apoptotic effect of Sph3, asphigomyelinase hemolysin from Leptospira interrogans strain Lai. BMB Rep. 2008. 41(2):119-125. He P, Sheng YY, Shi YZ, Jiang XG, Qin JH, Zhang ZM, ZhaoGP, Guo XK*. Genetic diversity among major endemic strains of Leptospira interrogans in China. BMC Genomics. 2007. 8:204. Ying Zou, Guo XK, Mathieu Picardeau, HaiXu, Guoping Zhao. A comprehensive survey on isoleucine biosynthesis pathways in seven epidemic Leptospira interrogans reference strains of China. FEMS Microbiology Letters, 2007, 269(1):90–96. Li QT,Zhu YZ, Chu JY,Wang YY, Xu YH, Hou QM, Zhang SM,Guo XK*. Protective immunity against Bordetellapertussis by a recombinant DNA vaccine and the effect of coinjection with agranulocyte- macrophage colony stimulating factor gene. Microbiol Immunol, 2006,50(12):929-936. Sun JC,Xu JL, Cao JP,Liu Q, Guo XK*, Shi TL. Predictionand systematic study of protein-protein interaction networks of Leptospira interrogans. Chinese Science Bulletin, 2006, 51(1):1-10. Yang HL, Zhu YZ, Qin JH, He P, Jiang XC, Zhao GP, Guo XK.In silico and microarray-based genomic approaches to identifying potential vaccine candidates against Leptospira interrogans. BMC Genomics. 2006. 16;7:293. Li QT, Zhu YZ, Chu JY, Dong K, He P, Feng CY, Hu BY,Zhang SM, Guo XK. Granulocyte-macrophage colony-stimulating factor DNA prime-protein boost strategy to enhance efficacy of a recombinant pertussis DNA vaccine. Acta Pharmacol Sin. 2006 Nov;27(11):1487-1494. Qin JH, Sheng YY, Zhang ZM, Shi YZ, He P, Hu BY, Yang Y,Liu SG, Zhao GP, Guo XK. Genome-wide transcriptional analysis of temperature shiftinL. interrogansserovarlai strain 56601.BMC Microbiol. 2006 Jun9;6:51. Li ZH, Dong K, Yuan JP, Hu BY, Liu JX, Zhao GP, Guo XK. Characterization of the cheY genes from Leptospira interrogans and their effects on the behavior of Escherichia coli. Biochem Biophys Res Commun. 2006; 345(2):858-866. Guo XK, Zhao WQ, Kondo C, Shimojo N, Yamashita K, Aoki T, Hayakawa T. Tissue inhibitors of metalloproteinases-1 (TIMP-1) and-2(TIMP-2) are major serum factors that stimulate the TIMP-1 gene in human gingival fibroblasts. Biochim Biophys Acta. 2006; 1763(3):296-304. Li ZH, Dong K, Sun JC, Yuan JP, Hu BY, Liu JX, Zhao GP,Guo XK. Characterization of cheW genes of Leptospirainterrogansand their effects in Escherichia coli.Acta Biochim Biophys Sin. 2006; 38(2):79-88. Yang HL, Jiang XC, Zhang XY, Li WJ, Hu BY, Zhao GP, Guo XK. Thrombocytopenia in the experimental leptospirosis ofguinea pig is not related to disseminated intravascular coagulation.BMC Infect Dis. 2006 Feb 2;6:19. Zhang XY, Yu Y, He P, Zhang YX, Hu BY, Yang Y, NieYX,Jiang XG, Zhao GP, Guo XK. Expression and comparative analysis of genes encoding outer membrane proteins LipL21, LipL32 and OmpL1 in epidemic leptospires. Acta Biochim Biophys Sin. 2005; 37(10):649-656. Zhang YX, Geng Y, Bi B, He JY, Wu CF, Guo XK, Zhao GP. Identification and classification of all potential hemolysin encoding genes and their products from Leptospira interrogans serogroup Icterohae-morrhagiae serovar Lai. Acta Pharmacol Sin. 2005; 26(4): 453-461. Wang HT, Li ZH, Yuan JP, Zhao W, Shi XD, Tong SQ, Guo XK. Effect of Helicobacter pylori VacA on gene expression of gastric cancer cells. World J Gastroenterol. 2005; 11(1):109-13. Yuan JP, Li T, Chen HB, Li ZH, Yang GZ, Hu BY, Shi XD,Tong SQ, Li YX, Guo XK. Analysis of gene expression profile in gastric cancercells stimulated with Helicobacter pylori isogenic strains. J Med Microbiol. 2004; 53(Pt 10):965-974. . Li ZH, Nie BM, Chen H, Chen SY, He P, Lu Y,Guo XK, Liu JX. In vitro anti-coxsackie virusB(3) effect of ethyl acetateextract of Tian-hua-fen. World J Gastroenterol. 2004; 10(15):2263-6. Zhang YX, Guo XK, Wu C, Bi B, Ren SX, Wu CF, ZhaoGP. Characterization of a novel toxin-antitoxin module,VapBC, encoded by Leptospira interrogans chromosome. Cell Res. 2004; 14(3):208-216. Yuan JP, Li T, Li ZH, Yang GZ, Hu BY, Shi XD, Shi TL,Tong SQ, Guo XK.mRNA expression profiling reveals a role of Helicobacter pylori vacuolating toxin in escaping host defense. World J Gastroenterol. 2004; 10(10):1528-1532. He P,Zhang XY, Guo XK, Hu BY, Huang XT,Yang Y, Zhao GP. Identification and analysis of genes present in Leptospira interrogans serovar Lai but absent in L. biflexa serovar monvalerio. Acta Biochim Biophysica Sin, 2004, 36(12):832-839. XuH,Zhang Y, Guo XK, Ren S, StaempfliAA, Chiao J, Jiang W, Zhao G. Isoleucine biosynthesis in Leptospirainterrogans serotype lai strain 56601 proceeds via a threonine-independent pathway. J. Bacteriol, 2004, 186(16): 5400-5409. Yuan JP, Li T, Shi XD, Hu BY, Yang GZ, Tong SQ, Guo XK. Deletion of Helicobacter pylori vacuolating cytotoxingene by introduction of directed mutagenesis.World J Gastroenterol.2003; 9(10):2251-7. Yuan JP, Zhao W, Wang HT, Wu KY, Li T, Guo XK, Tong SQ. Coxsackie virus B3-induced apoptosis and caspase-3.Cell Res. 2003; 13(3):203- 209. Ren SX, Fu G, Jiang XG, Zeng R, Miao YG, Xu H, ZhangYX, Xiong H, Lu G, Lu LF, Jiang HQ, Jia J, Tu YF, Jiang JX, Gu WY, Zhang YQ,Cai Z, Sheng HH, Yin HF, Zhang Y, Zhu GF, Wan M, Huang HL, Qian Z, Wang SY, MaW, Yao ZJ, Shen Y, Qiang BQ, Xia QC, Guo XK, Danchin A, Saint GironsI,Somerville RL, Wen YM, Shi MH, Chen Z, Xu JG, Zhao GP.Unique physiological and pathogenicfeatures of Leptospira interrogans revealed by whole-genome sequencing. Nature. 2003; 422(6934):888-893. Zhao WQ, Li H, Yamashita-K, Guo XK, Hayakawa-T. Cell cycle- associated accumulation of tissue inhibitor of metalloproteinases-1 (TIMP-1) in the nuclei of human gingival fibroblasts. Journalof Cell Science, 1998, 111:1147-1153.左建平的代表论著1. Xu YB, Yang L, Wang GF, Tong XK, Wang YJ, Yu Y, Jing JF, Feng CL, He PL, Lu W, Tang W, Zuo JP*. Benzimidazole Derivative, BM601, a Novel Inhibitor of Hepatitis B Virus and HBsg Secretion. Antiviral Res.2. Yang L, Shi LP, Chen HJ, Tong XK, Wang GF, Zhang YM, Wang WL, Feng CL, He PL, Zhu FH, Hao YH, Wang BJ, Yang DL, Tang W, Nan FJ, Zuo JP*. Isothiafludine, a novel non-nucleoside compound, inhibits hepatitis B virus replication through blocking pregenomic RNA encapsidation. Acta Pharmacol Sin.3. He SJ, Lin ZM, Zhang XH, Wu YW, Bai BX, Yang XQ, He PL, Zhu FH, Tang W*, Zuo JP*. Therapeutic effect of a reversible S-adenosyl-L-homocysteine hydrolase inhibitor in lupus-prone NZB×NZW F1 mice via interfering Toll-like receptor engaged antigen-presenting cell responses. Acta Pharmacol Sin.4. Li X, Li TT, Zhang XH, Hou LF, Yang XQ, Zhu FH, Tang W*, Zuo JP*. Artemisinin Analogue SM934 Ameliorates Murine Experimental Autoimmune Encephalomyelitis through Enhancing the Expansion and Functions of Regulatory T Cell. PLoS One.5. Kong FY, Chen W, He SJ, Lin ZM, Li X, Zhang XH, Yang XQ, Zhu FH, Tong XK, Zhou Y, Tang W, Duan WH*, Zuo JP*. Mycophenolic Acid Derivative 118 Treated Acute Skin Grafting Diseases through Suppressing the IL-17 Production. Acta Pharmacol Sin6. Wan CP, Gao LX, Hou LF, Yang XQ, He PL, Yang YF, Tang W, Yue JM*, Li J*, Zuo JP*. Astragaloside triggers T cell activation through regulating the activity of CD45 protein tyrosine phosphatase. Acta Pharmacol Sin.7. Shi JJ, Ji FH, He PL, Yang YX, Tang W, Zuo JP, Li YC. Synthesis and hepatitis C antiviral activity of 1-aminobenzyl-1H-indazole-3-carboxamide analogues. ChemMedChem8. Lu Y, Chen B, Song JH, Zhen T, Wang BY, Li X, Liu P, Yang X, Zhang QL, Xi XD, Chen SD, Zuo JP, Chen Z, Chen SJ. Eriocalyxin B ameliorates experimental autoimmune encephalomyelitis by suppressing Th1 and Th17 cells. Proc Natl Acad Sci U S A.9. Du YJ, Lin ZM, Zhao YH, Feng XP, Wang CQ, Wang G, Wang CD, Shi W, Zuo JP, Li F, Wang CZ. Stability of the recombinant anti?erbB2 scFv?Fc?interleukin?2 fusion protein and its inhibition of HER2?overexpressing tumor cells. Int J Oncol.10. Feng E, Shin WJ, Zhu X, Li J, Ye D, Wang J, Zheng M, Zuo JP, No KT, Liu X, Zhu W, Tang W, Seong BL, Jiang H, Liu H. Structure-Based Design and Synthesis of C-1- and C-4-Modified Analogs of Zanamivir as Neuraminidase Inhibitors. J Med Chem11. Zhang B, Wang Y, Yang SP, Zhou Y, Wu WB, Tang W, Zuo JP, Li Y, Yue JM. Ivorenolide A, an unprecedented immunosuppressive macrolide from Khaya ivorensis: structural elucidation and bioinspired total synthesis. J Am Chem12. Tang W, Zuo JP*. Immunosuppressant discovery from Tripterygium wilfordii Hook f: the novel triptolide analog (5R)-5-hydroxytriptolide (LLDT-8). Acta Pharmacol Sin13. Ye D, Shin WJ, Li N, Tang W, Feng E, Li J, He PL, Zuo JP, Kim H, Nam KY, Zhu W, Seong BL, Tai No K, Jiang H, Liu H. Synthesis of C-4-modified zanamivir analogs as neuraminidase inhibitors and their anti-AIV activities. Eur J Med Chem.14. Hou LF, He SJ, Li X, Wan CP, Yang Y, Zhang XH, He PL, Zhou Y, Zhu FH, Yang YF, LiY, Tang W, Zuo JP*. SM934 Treated Lupus-prone NZB × NZW F1 Mice by Enhancing Macrophage Interleukin-10 Production and Suppressing Pathogenic T Cell Development. PLoS ONE.15. Deng J, Li N, Liu H, Zuo Z, Liew OW, Xu W, Chen G, Tong X, Tang W, Zhu J, Zuo J, Jiang H, Yang CG*, Li J*, Zhu W*. Discovery of Novel Small Molecule Inhibitors of Dengue Viral NS2B-NS3 Protease Using Virtual Screening and Scaffold Hopping. J Med Chem.16. Liu MM, Zhou L, He PL, Zhang YN, Zhou JY, Shen Q, Chen XW, Zuo JP*, Li W*, Ye DY*. Discovery of flavonoid derivatives as anti-HCV agents via pharmacophore search combining molcular docking strategy. Eur J Med Chem17. Wu J, Zhou Y, Wang LY, Zuo JP, Zhao WM*. Terpenoids from root bark of Celastrus orbiculatus. Phytochemistry18. Chao B, Tong XK, Tang W, Li DW, He PL, Jean-Michel Garcia, Zeng LM, Gao AH, Yang L, Li J, Nan FJ, Michael Jacobs, Ralf Altmeyer, Zuo JP*, Hu YH*. Discovery and optimization of 2,4-diaminoquinazoline derivatives as a new class of potent dengue virus inhibitors. J Med Chem.19. Zhang M, Yang XY, Tang W, Tom W.L.Groeneveld, He PL, Zhu FH, Li J, Lu W, Anna M. Blom, Zuo JP*, Nan FJ*. Discovery and Structural Modification of 1-Phenyl-3-(1-phenylethyl)urea Derivatives as Inhibitors of Complement. ACS Medicinal Chemistry Letters.20. Feng XJ, Yang XY, Luo Y, Li X, Tang W, Zuo JP*, Lu W*. Synthesis and immunomodulating activity of new analogues of fingolimod. Arch Pharm (Weinheim)21. Wang LY, Chen ZH, Zhou Y, Tang W, Zuo JP, Zhao WM*. Structural revision of periplocosides and periperoxides, natural immunosuppressive agents from the genus Periploca. Phytochemistry.22. Xie H, Lin L, Tong L, Jiang Y, Zheng M, Chen Z, Jiang X, Zhang X, Ren X, Qu W, Yang Y, Wan H, Chen Y, Zuo J, Jiang H, Geng M, Ding J*. AST1306, A Novel Irreversible Inhibitor of the Epidermal Growth Factor Receptor 1 and 2, Exhibits Antitumor Activity Both In Vitro and In Vivo. PLoS One23. Hou LF, He SJ, Li X, Yang Y, He PL, Zhou Y, Zhu FH, Yang YF, Li Y, Tang W, Zuo JP*. Oral administration of Artemisinin analogue SM934 ameliorated the lupus syndromes in MRL/lpr mice by inhibiting Th1 and Th17 cell responses. Arthritis & Rheumatism.24. Qu SJ, Wang GF, Duan WH, Yao SY, Zuo JP*, Tan CH*, Zhu DY. Tryptamine derivatives as novel non-nucleosidic inhibitors against hepatitis B virus. Bioorg Med Chem25. Luo Y, Yao JP, Yang L, Feng CL, Tang W, Wang GF, Zuo JP*, Lu W*. Synthesis and anti-hepatitis B virus activity of a novel class of thiazolylbenzimidazole derivatives. Arch Pharm (Weinheim).26. Wang HB, Zuo JP, Qin GW*. One new sesquiterpene from Saussurea laniceps. Fitoterapia.27. Luo Y, Yao JP, Yang L, Feng CL, Tang W, Wang GF, Zuo JP*, Lu W. Design and synthesis of novel benzimidazole derivatives as inhibitors of hepatitis B virus. Bioorg Med Chem28. Tong XK, Qiu H, Zhang X, Shi LP, Wang GF, Ji FH, Ding HY, Tang W, Ding K*, Zuo JP*. WSS45, a sulfated alpha-D-glucan, strongly interferes with Dengue 2 virus infection in vitro. Acta Pharmacol Sin. 2010 May29. Ni J, Zhu YN, Zhong XG, Ding Y, Hou LF, Tong XK, Tang W, Ono S, Yang YF*, Zuo JP*. The chemokine receptor antagonist, TAK-779, decreased experimental autoimmune encephalomyelitis by reducing inflammatory cell migration into the central nervous system, without affecting T cell function. Br J Pharmacol.30. Hou LF, He SJ, Wang JX, Yang Y, Zhu FH, Zhou Y, He PL, Zhang Y, Yang YF, Li Y*, Wei Tang W*, Zuo JP*. SM934, a water-soluble derivative of arteminisin, exerts immunosuppressive functions in vitro and in vivo. Int Immunopharmacol.31. Wang JX, Hou LF, Yang Y, Tang W, Li Y, Zuo JP*. Inhibition of NO and pro-inflammatory cytokine production by SM905, a novel artemisinin derivative, is associated with suppression of MAPK and NF-κB pathways in RAW 264.7 macrophages. Acta Pharmacol Sin.32. Zhang J, Ni J, Chen ZH, Li X, Zhang RJ, Tang W, Zhao WM, Yang YF*, Zuo JP*. Periplocoside A prevents experimental autoimmune encephalomyelitis by suppressing IL-17 production and inhibits differentiation of Th17 cells. Acta Pharmacol Sin.33. Wang GF#, Shi LP#, Ren YD#, Liu QF, Liu HF, Zhang RJ, Li Z, Zhu FH, He PL, Tang W, Tao PZ, Li C, Zhao WM, Zuo JP*. Anti-hepatitis B virus activity of chlorogenic acid, quinic acid and caffeic acid in vivo and in vitro. Antiviral Res34. Garcia JM, Gao A, He PL, Choi J, Tang W, Bruzzone R, Schwartz O, Naya H, Nan FJ*, Li J*, Altmeyer R, Zuo JP*. High-throughput screening using pseudotyped lentiviral particles: A strategy for the identification of HIV-1 inhibitors in a cell-based assay. Antiviral Res.35. Zhou R, Tang W, He PL, Yang YF, Li YC, Zuo JP*. (5R)-5-hydroxytriptolide inhibits the immune response of human peripheral blood mononuclear cells. Int Immunopharmacol.。
- 郭晓奎的个人作品
- 左建平的代表论著
郭晓奎（主编）病原生物学-医学微生物学 科学出版社 2012
郭晓奎（主编）病原生物学-医学寄生虫学 科学出版社 2012
郭晓奎（主审）医学微生物学实验教程 人民卫生出版社 2011
郭晓奎（主编）医学微生物学实验技术 人民卫生出版社 2010
郭晓奎(主编) 感染与优生优育 第二军医大学出版社 上海 2009
郭晓奎（主编）病原生物学教育教学 第二军医大学出版社 上海 2008
郭晓奎（主编）病原生物学纲要（英文版） 科学出版社 2008
郭晓奎（主编）病原生物学 科学出版社 2007
郭晓奎(主编) 细胞微生物学 第二军医大学出版社 上海 2004
郭晓奎(主编) 克隆识别 北京医科大学和中国协和大学联合出版社 北京1994 Zhang ZY, Sun ZQ, Wang ZL, Hu HR, Wen ZL, Song YZ, Zhao JW, Wang HH, Guo XK*, Zhang SL. Identification and pathogenicity analysis of a novel non-tuberculous mycobacterium clinical isolate with nine-antibiotic resistance.Clin Microbiol Infect.2013; 19(1):91-6. Zhang SM,Qiu J,Tian F,Guo XK,Zhang FQ,Huang QFCorrosion behavior of pure titanium in the presence of Actinomyces naeslundii.J Mater Sci Mater Med.2013 Feb 21. [Epub ahead of print] Zelin Cui, Yuhua Zhou, Hong Li, Yan Zhang, Shenjie Tang, Xiaokui Guo. Complex sputum microbial composition in patients with pulmonary tuberculosis. BMC microbiology. 2012, 12:276 Zelin Cui, WenbinShen, Zheng Wang, Haotian Zhang, Rao Me, Yanchun Wang, LingbingZeng, Yongzhang Zhu, Jinhong Qin, Ping He, and Xiao-Kui Guo*. Complete Genome Sequence of Klebsiellapneumoniae phage JD001. Journal of Virology. 2012, 86(24):13843. Zelin Cui, Zhen Song, Yanchun Wang, LingbingZeng, WenbinShen, Zheng Wang, Qingtian Li, Ping He, Jinhong Qin, and Xiao-Kui Guo*. Complete Genome Sequence of wide host-range Staphylococcus aureus phage JD007. Journal of Virology. 2012, 86(24):13880. Zhou Y, Tao J, Yu H, Ni JJ, Zeng LB, Teng QH, Kim K, Zhao GP, Guo XK*, and Yao YF. Hcp-family proteins secreted via type VI secretion system coordinately regulate Escherichia coli K1 interaction with human brain microvascular endothelial cells. Infection and Immunity, 2012 , 80(3):1243-51 Zhang ZY, Liu C, Zhu YZ, Wei YX, Tian F, Zhao GP, Guo XK*. Safety assessment of Lactobacillus plantarumJDM1 based on the complete genome. Int J Food Microbiol. 2012 Feb 1;153(1-2):166-70. Epub 2011 Nov 12. Wei YX, Zhang ZY, Liu C, Malakar PK, Guo XK*.Safety assessment of Bifidobacterium longum JDM301 based on complete genome sequences.World J Gastroenterol. 2012 Feb 7;18(5):479-88. Zhang MM, Zhao JW, Sun ZQ, Liu J, Guo XK, Liu WD, Zhang SL. Identification of RD5-encoded Mycobacterium tuberculosis proteins as B-cell antigens used for serodiagnosis of tuberculosis. Clin Dev Immunol. 2012; 2012:738043. Zhang Y, Lou XL, Yang HL, Guo XK, Zhang XY, He P, Jiang XC. Establishment of a leptospirosis model in guinea pigs using an epicutaneous inoculations route.BMC Infect Dis. 2012 Jan 25;12:20. Li QT, Huang JW, Guo HX, Guo XK, Zhu YZ, Dong K. Bactericidal activity against meticillin-resistant Staphylococcus aureus of a novel eukaryotic therapeutic recombinant antimicrobialpeptide.IntJ Antimicrob Agents, 2012, 39 (6):496-499. Peng N, Zhong Y, Zhang Q, Zheng M, Zhao W, Jiang H, Yang C, Guo X, Zhao G.Characterization of acetyl-CoA and propionyl-CoA carboxylases encoded by Leptospira interrogans serovar Lai: an initial biochemical study for leptospiral gluconeogenesis via anapleroticCO(2) assimilation. Acta Biochim Biophys Sin. 2012;44(8):692-702. Shi, Si-feng, Jia, Jing-fu, Guo, Xiao-kui, Zhao, Ya-ping, Liu, Bo-yu, Chen, De-sheng, Guo, Yong-yuan, Zhang, Xian-long. Toxicity of iron oxide nanoparticles against osteoblasts. JOURNAL OF NANOPARTICLE RESEARCH 2012; 14(9),1091, Zheng LL, Li YX, Ding J, Guo XK, Feng KY, Wang YJ, Hu LL, Cai YD, Hao P, Chou KC. A comparison of computational methods for identifying virulence factors. PLoS One. 2012; 7(8):e42517. Shi SF, Jia JF, Guo XK, Zhao YP, Chen DS, Guo YY, Cheng T, Zhang XL.Biocompatibility of chitosan-coated iron oxide nanoparticles with osteoblast cells.Int J Nanomedicine. 2012; 7:5593-602. Li QT, Zhu YZ, Dong K, Liu C, Zhou YH, Ni YX, Guo XK*. A novel sequence-based coa genotyping method to discriminate nosocomial ethicillin-resistant Staphylococcus aureus isolates. Ir J Med Sci. 2011, 180 (2): 463-8. Zhong Y, Chang X, Cao XJ, Zhang Y, Zheng H, Zhu Y, Cai C, Cui Z, Zhang Y, Li YY, Jiang XG, Zhao GP, Wang S, Li Y, Zeng R, Li X, Guo XK*. Comparative proteogenomic analysis of the Leptospira interrogans virulence-attenuated strain IPAV against the pathogenic strain 56601. Cell Res. 2011, 21 (8): 1210-29. Zhao JW, Sun ZQ, Zhang CZ, Yang HG, Yu XL, Wen ZL, Gao YF, Guo XK, Qi YM, Zhang SL. Cloning, expression and immunological evaluation of a short fragment from Rv3391 of Mycobacterium tuberculosis . Ann Microbiol. 2011, 61 (2): 345-353 Zhang ZY, Sun ZQ, Wang ZL, Wen ZL, Sun QW, Zhu ZQ, Song YZ, Zhao JW, Wang HH, Zhang SL, Guo XK*. Complete genome of a novel clinical isolated non-tuberculous mycobacterium strain JDM601.J Bacteriol. 2011, 193 (16): 4300-1. Zhang SM, Tian F, Huang QF, Zhao YF, Guo XK, Zhang FQ. Bacterial diversity of subgingival plaque in 6 healthy Chinese individuals.Exp Ther Med.2011; 2(5):1023-1029. Zhang Q, Zhang Y, Zhong Y, Ma J, Peng N, Cao X, Yang C, Zeng R, Guo X, Zhao G. Leptospira interrogans encodes an ROK family glucokinase involved in a cryptic glucose utilization pathway. Acta Biochim Biophys Sin . 2011, 43 (8): 618-29. Ning R, Zhang X, Guo X, Li Q. Staphylococcus aureus regulates secretion of interleukin-6 and monocyte chemoattractant protein-1 through activation of nuclear factor kappaB signaling pathway in human osteoblasts. Braz J Infect Dis. 2011, 15 (3): 189-94. Ning R, Zhang X, Guo X, Li Q. Attachment of Staphylococcus aureus is required for activation of nuclear factor kappa B in human osteoblasts. Acta Biochim Biophys Sin. 2010, 42(12): 883-92. Zhu YZ, Cai CS, Zhang W, Guo HX, Zhang JP, Ji YY, Ma GY,Wu JL, Li QT, Lu CP, Guo XK*. Immunoproteomic analysis of human serological antibodyresponses to vaccination with whole-cell pertussis vaccine (WCV). PLoS One. 2010; 5(11):e13915. YuhuaZhou, Ping Lin, Qingtian Li, Lizhong Han, HuajunZheng, Yanxia Wei, Zelin Cui, Yuxing Ni, XiaokuiGuo*. Analysis of the microbiota of sputum samples from patients with lower respiratory tract infections. Acta Biochim Biophys Sin. 2010;42(10):754-761. Wu,Chenyun; Fen, Yan; Qian, Gaochao; Wu, Jianhua; Luo, Jun; Wang, Ying; Chen,Guangjie; Guo, Xiaokui*; Wang, Zhaojun*. α-galactosylceramide protects mice from lethal coxsackie virus B3 infection and subsequent myocarditis. Clin Exp Immunol. 2010, 162(1):178-187. Wei YX, Zhang ZY, Liu C, Zhu YZ, Zhu YQ, Zheng H, ZhaoGP, Wang S, Guo XK*.Complete genome sequence of Bifidobacterium longum JDM301. J Bacteriol. 2010; 192(15):4076-7. Qingtian Li,Yuhua Zhou ,Ke Dong ,Xiaokui Guo*. Potential therapeuticefficacy of a bactericidal–immunomodulatory fusion peptide againstmethicillin-resistant Staphylococcus aureus skin infection. 2010. Appl Microbiol Biotechnol . 2010, 86:305–309. Cai CS, Zhu YZ, Zhong Y, Xin XF, Jiang XG, Lou XL, He P,Qin JH, Zhao GP, Wang SY, Guo XK*.Development of O-antigen gene cluster-specific PCRs forrapid typing six epidemic serogroups of Leptospira in China. BMC Microbiol. 2010; 10:67. Liu C, Zhang ZY, Dong K, Guo XK. Adhesion and immunomodulatory effects of Bifidobacte riumlactis HN019 on intestinal epithelial cells INT-407. World J Gastroentero.2010; 16(18):2283-90. Ke Dong, Qingtian Li, Chang Liu, Yunyi Zhang, Guoping Zhao, and Xiaokui Guo. Cloning and characterization of three cheB genes in Leptospira interrogans. Acta Biochim Biophys Sin . 2010, 42 (3): 216-223. Yang J,Xu J, Chen X, Zhang Y, Jiang X, XiaokuiGuo, and Guoping Zhao. Decrease of Plasma Platelet-Activating Factor Acetylhydrolase Activity inLipopolysaccharide Induced Mongolian Gerbil Sepsis Model. PLoS ONE 2010, 5(2): e9190. Cao XJ, Dai J, Xu H, Nie S, Chang X, Hu BY, Sheng QH,Wang LS, Ning ZB, Li YX, Guo XK, Zhao GP, Zeng R. High-coverage proteome analysis reveals the first insight of protein modification systems in the pathogenic spirochete Leptospira interrogans. Cell Res. 2010; 20(2):197-210. Lin W, Yang HL, Yang Y, Hu BY, Tan LZ, Guo XK. Cloning, expression, and immunologicalevaluation of a novel protein belonging to OmpA family in Leptospira interrogans Recent Works on Microbes andInfections in China, World Scientific Publishing Co. Pte. Ltd. , 2009.P1-12 Jiang,XG, Zhang XY, Zhong WJ, Nie YX, Yin WW, Li XW, Guo XK Surveillance of Leptospirosis and the MurineReservoirs in China 2005 Recent Works on Microbes and Infections in China,World Scientific Publishing Co. Pte. Ltd, 2009. P13-19. Yao Y,Xie Y, Perace D, Zhong Y, Lu J, Tao J,Guo XK, Kim KS.The type IIIsecretion system is involved in the invasion and intracellular survival ofEscherichia coli K1 in humanbrainmicrovascular endothelial cells.FEMS Microbiol Lett. 2009, 300(1):18-24. JianpingYuan, Ping Li, Jing Tao, Xiaodong Shi, Baoyu Hu, Huabiao Chen and XiaokuiGuo* H.pylori Escape Host Immunoreaction Through Inhibiting ILKExpressionByVacA.Cellular & Molecular Immunology, 2009, 6(3): 191-197. Zhang ZY, Liu C, Zhu YZ, Zhong Y, Zhu YQ, Zheng HJ, ZhaoGP, Wang SY, Guo XK. Complete genome sequence of Lactobacillus plantarum JDM1.J Bacteriol. 2009Aug;191(15):5020-5021. Zhang SM, Tian F, Jiang XQ, Li J, Xu C, Guo XK, Zhang FQ.Evidence for calcifying nanoparticles in gingivalcrevicular fluid and dental calculus in periodontitis. J Periodontol. 2009; 80(9):1462-70. TianF,Yu Y, Chen B, Li HR, Yao YF, Guo XK*. Bacterial, archaeal and eukaryotic diversity in Arctic sediment as revealed by16S rRNA and 18S rRNA gene clone libraries analysis. Polar Biology, 2009, 32(1):93-103. Zhao W, Chen CY, Zhang XY, Lai WQ, Hu BY, Zhao GP, QinJH, Guo XK*. Molecular characterization of the pL40 protein inLeptospirainterrogans. Can J Microbiol. 2009; 55(6):739-749. FengCY, Li QT, Zhang XY, Dong K, Hu BY,GuoXK. Immune strategies on single component LipL32 and multi-components recombinant LipL32-41-OmpL1 vaccines against Leptospira. Brazilian Journal of Medical and BiologicalResearch. 2009, 42(9):796-803 Liu C, Zhang ZY, Dong K, Yuan JP, Guo XK*.Antibiotic resistance of probiotic strains of lactic acidbacteria isolated from marketed foods and drugs. Biomed Environ Sci. 2009; 22(5):401-412. Qin Lu,De-Hong Yu, Chao Fang, Fang Liu, Xun Ye, Yi Zhao, Jie Qin, Xiao-KuiGuo, Min Liang, Fang Hu and Hong-zhuan Chen. Influence of E3 region on conditionally replicative adenovirus mediated cytotoxicity in hepatocellular carcinoma cells. Cancer biology and therapy, 2009, 8(12): 1127-1134. Yang RF,Guo XK, Yang J, Jiang YQ, Pang B,Chen C, Yao YF, Qin JH, Li QT. Genomic research for important pathogenic bacteria in China. Science in China Series C: Life Sciences, 2009, 52(1):50-63. JunweiYang, Yixuan Zhang, Jing Xu, Yan Geng, Xiaoying Chen, Hongling Yang, ShengnanWang, Hengan Wang,Xucheng Jiang, XiaokuiGuo, Guoping Zhao. Serum activity of platelet-activating factoracetylhydrolase is a potential clinical marker for leptospirosis pulmonaryhemorrhage.PloS ONE. 2009 4(1): e4181. Zhu YZ, Li QT, Wang L, Zhong Y, Ding GH, Li G, JiaPL,Shi TL, Guo XK*. Gene expression profiling-based in silico approach toidentify potential vaccine candidates and drug targets against B. pertussis and B. parapertussis.OMICS. 2008 ;12(3):161-169. Qin JH, Zhang Q, Zhang ZM, Zhong Y, Yang Y, Hu BY, ZhaoGP, Guo XK*. Identification of a novel prophage-like gene cluster actively expressed in both virulent and avirulent strains of Leptospira interrogans serovar Lai. Infect Immun. 2008; 76(6):2411-2419. Zhang YX, Geng Y, Yang JW, Guo XK, Zhao GP. Cytotoxic activity and probable apoptotic effect of Sph3, asphigomyelinase hemolysin from Leptospira interrogans strain Lai. BMB Rep. 2008. 41(2):119-125. He P, Sheng YY, Shi YZ, Jiang XG, Qin JH, Zhang ZM, ZhaoGP, Guo XK*. Genetic diversity among major endemic strains of Leptospira interrogans in China. BMC Genomics. 2007. 8:204. Ying Zou, Guo XK, Mathieu Picardeau, HaiXu, Guoping Zhao. A comprehensive survey on isoleucine biosynthesis pathways in seven epidemic Leptospira interrogans reference strains of China. FEMS Microbiology Letters, 2007, 269(1):90–96. Li QT,Zhu YZ, Chu JY,Wang YY, Xu YH, Hou QM, Zhang SM,Guo XK*. Protective immunity against Bordetellapertussis by a recombinant DNA vaccine and the effect of coinjection with agranulocyte- macrophage colony stimulating factor gene. Microbiol Immunol, 2006,50(12):929-936. Sun JC,Xu JL, Cao JP,Liu Q, Guo XK*, Shi TL. Predictionand systematic study of protein-protein interaction networks of Leptospira interrogans. Chinese Science Bulletin, 2006, 51(1):1-10. Yang HL, Zhu YZ, Qin JH, He P, Jiang XC, Zhao GP, Guo XK.In silico and microarray-based genomic approaches to identifying potential vaccine candidates against Leptospira interrogans. BMC Genomics. 2006. 16;7:293. Li QT, Zhu YZ, Chu JY, Dong K, He P, Feng CY, Hu BY,Zhang SM, Guo XK. Granulocyte-macrophage colony-stimulating factor DNA prime-protein boost strategy to enhance efficacy of a recombinant pertussis DNA vaccine. Acta Pharmacol Sin. 2006 Nov;27(11):1487-1494. Qin JH, Sheng YY, Zhang ZM, Shi YZ, He P, Hu BY, Yang Y,Liu SG, Zhao GP, Guo XK. Genome-wide transcriptional analysis of temperature shiftinL. interrogansserovarlai strain 56601.BMC Microbiol. 2006 Jun9;6:51. Li ZH, Dong K, Yuan JP, Hu BY, Liu JX, Zhao GP, Guo XK. Characterization of the cheY genes from Leptospira interrogans and their effects on the behavior of Escherichia coli. Biochem Biophys Res Commun. 2006; 345(2):858-866. Guo XK, Zhao WQ, Kondo C, Shimojo N, Yamashita K, Aoki T, Hayakawa T. Tissue inhibitors of metalloproteinases-1 (TIMP-1) and-2(TIMP-2) are major serum factors that stimulate the TIMP-1 gene in human gingival fibroblasts. Biochim Biophys Acta. 2006; 1763(3):296-304. Li ZH, Dong K, Sun JC, Yuan JP, Hu BY, Liu JX, Zhao GP,Guo XK. Characterization of cheW genes of Leptospirainterrogansand their effects in Escherichia coli.Acta Biochim Biophys Sin. 2006; 38(2):79-88. Yang HL, Jiang XC, Zhang XY, Li WJ, Hu BY, Zhao GP, Guo XK. Thrombocytopenia in the experimental leptospirosis ofguinea pig is not related to disseminated intravascular coagulation.BMC Infect Dis. 2006 Feb 2;6:19. Zhang XY, Yu Y, He P, Zhang YX, Hu BY, Yang Y, NieYX,Jiang XG, Zhao GP, Guo XK. Expression and comparative analysis of genes encoding outer membrane proteins LipL21, LipL32 and OmpL1 in epidemic leptospires. Acta Biochim Biophys Sin. 2005; 37(10):649-656. Zhang YX, Geng Y, Bi B, He JY, Wu CF, Guo XK, Zhao GP. Identification and classification of all potential hemolysin encoding genes and their products from Leptospira interrogans serogroup Icterohae-morrhagiae serovar Lai. Acta Pharmacol Sin. 2005; 26(4): 453-461. Wang HT, Li ZH, Yuan JP, Zhao W, Shi XD, Tong SQ, Guo XK. Effect of Helicobacter pylori VacA on gene expression of gastric cancer cells. World J Gastroenterol. 2005; 11(1):109-13. Yuan JP, Li T, Chen HB, Li ZH, Yang GZ, Hu BY, Shi XD,Tong SQ, Li YX, Guo XK. Analysis of gene expression profile in gastric cancercells stimulated with Helicobacter pylori isogenic strains. J Med Microbiol. 2004; 53(Pt 10):965-974. . Li ZH, Nie BM, Chen H, Chen SY, He P, Lu Y,Guo XK, Liu JX. In vitro anti-coxsackie virusB(3) effect of ethyl acetateextract of Tian-hua-fen. World J Gastroenterol. 2004; 10(15):2263-6. Zhang YX, Guo XK, Wu C, Bi B, Ren SX, Wu CF, ZhaoGP. Characterization of a novel toxin-antitoxin module,VapBC, encoded by Leptospira interrogans chromosome. Cell Res. 2004; 14(3):208-216. Yuan JP, Li T, Li ZH, Yang GZ, Hu BY, Shi XD, Shi TL,Tong SQ, Guo XK.mRNA expression profiling reveals a role of Helicobacter pylori vacuolating toxin in escaping host defense. World J Gastroenterol. 2004; 10(10):1528-1532. He P,Zhang XY, Guo XK, Hu BY, Huang XT,Yang Y, Zhao GP. Identification and analysis of genes present in Leptospira interrogans serovar Lai but absent in L. biflexa serovar monvalerio. Acta Biochim Biophysica Sin, 2004, 36(12):832-839. XuH,Zhang Y, Guo XK, Ren S, StaempfliAA, Chiao J, Jiang W, Zhao G. Isoleucine biosynthesis in Leptospirainterrogans serotype lai strain 56601 proceeds via a threonine-independent pathway. J. Bacteriol, 2004, 186(16): 5400-5409. Yuan JP, Li T, Shi XD, Hu BY, Yang GZ, Tong SQ, Guo XK. Deletion of Helicobacter pylori vacuolating cytotoxingene by introduction of directed mutagenesis.World J Gastroenterol.2003; 9(10):2251-7. Yuan JP, Zhao W, Wang HT, Wu KY, Li T, Guo XK, Tong SQ. Coxsackie virus B3-induced apoptosis and caspase-3.Cell Res. 2003; 13(3):203- 209. Ren SX, Fu G, Jiang XG, Zeng R, Miao YG, Xu H, ZhangYX, Xiong H, Lu G, Lu LF, Jiang HQ, Jia J, Tu YF, Jiang JX, Gu WY, Zhang YQ,Cai Z, Sheng HH, Yin HF, Zhang Y, Zhu GF, Wan M, Huang HL, Qian Z, Wang SY, MaW, Yao ZJ, Shen Y, Qiang BQ, Xia QC, Guo XK, Danchin A, Saint GironsI,Somerville RL, Wen YM, Shi MH, Chen Z, Xu JG, Zhao GP.Unique physiological and pathogenicfeatures of Leptospira interrogans revealed by whole-genome sequencing. Nature. 2003; 422(6934):888-893. Zhao WQ, Li H, Yamashita-K, Guo XK, Hayakawa-T. Cell cycle- associated accumulation of tissue inhibitor of metalloproteinases-1 (TIMP-1) in the nuclei of human gingival fibroblasts. Journalof Cell Science, 1998, 111:1147-1153.
1. Xu YB, Yang L, Wang GF, Tong XK, Wang YJ, Yu Y, Jing JF, Feng CL, He PL, Lu W, Tang W, Zuo JP*. Benzimidazole Derivative, BM601, a Novel Inhibitor of Hepatitis B Virus and HBsg Secretion. Antiviral Res.
2. Yang L, Shi LP, Chen HJ, Tong XK, Wang GF, Zhang YM, Wang WL, Feng CL, He PL, Zhu FH, Hao YH, Wang BJ, Yang DL, Tang W, Nan FJ, Zuo JP*. Isothiafludine, a novel non-nucleoside compound, inhibits hepatitis B virus replication through blocking pregenomic RNA encapsidation. Acta Pharmacol Sin.
3. He SJ, Lin ZM, Zhang XH, Wu YW, Bai BX, Yang XQ, He PL, Zhu FH, Tang W*, Zuo JP*. Therapeutic effect of a reversible S-adenosyl-L-homocysteine hydrolase inhibitor in lupus-prone NZB×NZW F1 mice via interfering Toll-like receptor engaged antigen-presenting cell responses. Acta Pharmacol Sin.
4. Li X, Li TT, Zhang XH, Hou LF, Yang XQ, Zhu FH, Tang W*, Zuo JP*. Artemisinin Analogue SM934 Ameliorates Murine Experimental Autoimmune Encephalomyelitis through Enhancing the Expansion and Functions of Regulatory T Cell. PLoS One.
5. Kong FY, Chen W, He SJ, Lin ZM, Li X, Zhang XH, Yang XQ, Zhu FH, Tong XK, Zhou Y, Tang W, Duan WH*, Zuo JP*. Mycophenolic Acid Derivative 118 Treated Acute Skin Grafting Diseases through Suppressing the IL-17 Production. Acta Pharmacol Sin
6. Wan CP, Gao LX, Hou LF, Yang XQ, He PL, Yang YF, Tang W, Yue JM*, Li J*, Zuo JP*. Astragaloside triggers T cell activation through regulating the activity of CD45 protein tyrosine phosphatase. Acta Pharmacol Sin.
7. Shi JJ, Ji FH, He PL, Yang YX, Tang W, Zuo JP, Li YC. Synthesis and hepatitis C antiviral activity of 1-aminobenzyl-1H-indazole-3-carboxamide analogues. ChemMedChem
8. Lu Y, Chen B, Song JH, Zhen T, Wang BY, Li X, Liu P, Yang X, Zhang QL, Xi XD, Chen SD, Zuo JP, Chen Z, Chen SJ. Eriocalyxin B ameliorates experimental autoimmune encephalomyelitis by suppressing Th1 and Th17 cells. Proc Natl Acad Sci U S A.
9. Du YJ, Lin ZM, Zhao YH, Feng XP, Wang CQ, Wang G, Wang CD, Shi W, Zuo JP, Li F, Wang CZ. Stability of the recombinant anti?erbB2 scFv?Fc?interleukin?2 fusion protein and its inhibition of HER2?overexpressing tumor cells. Int J Oncol.
10. Feng E, Shin WJ, Zhu X, Li J, Ye D, Wang J, Zheng M, Zuo JP, No KT, Liu X, Zhu W, Tang W, Seong BL, Jiang H, Liu H. Structure-Based Design and Synthesis of C-1- and C-4-Modified Analogs of Zanamivir as Neuraminidase Inhibitors. J Med Chem
11. Zhang B, Wang Y, Yang SP, Zhou Y, Wu WB, Tang W, Zuo JP, Li Y, Yue JM. Ivorenolide A, an unprecedented immunosuppressive macrolide from Khaya ivorensis: structural elucidation and bioinspired total synthesis. J Am Chem
12. Tang W, Zuo JP*. Immunosuppressant discovery from Tripterygium wilfordii Hook f: the novel triptolide analog (5R)-5-hydroxytriptolide (LLDT-8). Acta Pharmacol Sin
13. Ye D, Shin WJ, Li N, Tang W, Feng E, Li J, He PL, Zuo JP, Kim H, Nam KY, Zhu W, Seong BL, Tai No K, Jiang H, Liu H. Synthesis of C-4-modified zanamivir analogs as neuraminidase inhibitors and their anti-AIV activities. Eur J Med Chem.
14. Hou LF, He SJ, Li X, Wan CP, Yang Y, Zhang XH, He PL, Zhou Y, Zhu FH, Yang YF, LiY, Tang W, Zuo JP*. SM934 Treated Lupus-prone NZB × NZW F1 Mice by Enhancing Macrophage Interleukin-10 Production and Suppressing Pathogenic T Cell Development. PLoS ONE.
15. Deng J, Li N, Liu H, Zuo Z, Liew OW, Xu W, Chen G, Tong X, Tang W, Zhu J, Zuo J, Jiang H, Yang CG*, Li J*, Zhu W*. Discovery of Novel Small Molecule Inhibitors of Dengue Viral NS2B-NS3 Protease Using Virtual Screening and Scaffold Hopping. J Med Chem.
16. Liu MM, Zhou L, He PL, Zhang YN, Zhou JY, Shen Q, Chen XW, Zuo JP*, Li W*, Ye DY*. Discovery of flavonoid derivatives as anti-HCV agents via pharmacophore search combining molcular docking strategy. Eur J Med Chem
17. Wu J, Zhou Y, Wang LY, Zuo JP, Zhao WM*. Terpenoids from root bark of Celastrus orbiculatus. Phytochemistry
18. Chao B, Tong XK, Tang W, Li DW, He PL, Jean-Michel Garcia, Zeng LM, Gao AH, Yang L, Li J, Nan FJ, Michael Jacobs, Ralf Altmeyer, Zuo JP*, Hu YH*. Discovery and optimization of 2,4-diaminoquinazoline derivatives as a new class of potent dengue virus inhibitors. J Med Chem.
19. Zhang M, Yang XY, Tang W, Tom W.L.Groeneveld, He PL, Zhu FH, Li J, Lu W, Anna M. Blom, Zuo JP*, Nan FJ*. Discovery and Structural Modification of 1-Phenyl-3-(1-phenylethyl)urea Derivatives as Inhibitors of Complement. ACS Medicinal Chemistry Letters.
20. Feng XJ, Yang XY, Luo Y, Li X, Tang W, Zuo JP*, Lu W*. Synthesis and immunomodulating activity of new analogues of fingolimod. Arch Pharm (Weinheim)
21. Wang LY, Chen ZH, Zhou Y, Tang W, Zuo JP, Zhao WM*. Structural revision of periplocosides and periperoxides, natural immunosuppressive agents from the genus Periploca. Phytochemistry.
22. Xie H, Lin L, Tong L, Jiang Y, Zheng M, Chen Z, Jiang X, Zhang X, Ren X, Qu W, Yang Y, Wan H, Chen Y, Zuo J, Jiang H, Geng M, Ding J*. AST1306, A Novel Irreversible Inhibitor of the Epidermal Growth Factor Receptor 1 and 2, Exhibits Antitumor Activity Both In Vitro and In Vivo. PLoS One
23. Hou LF, He SJ, Li X, Yang Y, He PL, Zhou Y, Zhu FH, Yang YF, Li Y, Tang W, Zuo JP*. Oral administration of Artemisinin analogue SM934 ameliorated the lupus syndromes in MRL/lpr mice by inhibiting Th1 and Th17 cell responses. Arthritis & Rheumatism.
24. Qu SJ, Wang GF, Duan WH, Yao SY, Zuo JP*, Tan CH*, Zhu DY. Tryptamine derivatives as novel non-nucleosidic inhibitors against hepatitis B virus. Bioorg Med Chem
25. Luo Y, Yao JP, Yang L, Feng CL, Tang W, Wang GF, Zuo JP*, Lu W*. Synthesis and anti-hepatitis B virus activity of a novel class of thiazolylbenzimidazole derivatives. Arch Pharm (Weinheim).
26. Wang HB, Zuo JP, Qin GW*. One new sesquiterpene from Saussurea laniceps. Fitoterapia.
27. Luo Y, Yao JP, Yang L, Feng CL, Tang W, Wang GF, Zuo JP*, Lu W. Design and synthesis of novel benzimidazole derivatives as inhibitors of hepatitis B virus. Bioorg Med Chem
28. Tong XK, Qiu H, Zhang X, Shi LP, Wang GF, Ji FH, Ding HY, Tang W, Ding K*, Zuo JP*. WSS45, a sulfated alpha-D-glucan, strongly interferes with Dengue 2 virus infection in vitro. Acta Pharmacol Sin. 2010 May
29. Ni J, Zhu YN, Zhong XG, Ding Y, Hou LF, Tong XK, Tang W, Ono S, Yang YF*, Zuo JP*. The chemokine receptor antagonist, TAK-779, decreased experimental autoimmune encephalomyelitis by reducing inflammatory cell migration into the central nervous system, without affecting T cell function. Br J Pharmacol.
30. Hou LF, He SJ, Wang JX, Yang Y, Zhu FH, Zhou Y, He PL, Zhang Y, Yang YF, Li Y*, Wei Tang W*, Zuo JP*. SM934, a water-soluble derivative of arteminisin, exerts immunosuppressive functions in vitro and in vivo. Int Immunopharmacol.
31. Wang JX, Hou LF, Yang Y, Tang W, Li Y, Zuo JP*. Inhibition of NO and pro-inflammatory cytokine production by SM905, a novel artemisinin derivative, is associated with suppression of MAPK and NF-κB pathways in RAW 264.7 macrophages. Acta Pharmacol Sin.
32. Zhang J, Ni J, Chen ZH, Li X, Zhang RJ, Tang W, Zhao WM, Yang YF*, Zuo JP*. Periplocoside A prevents experimental autoimmune encephalomyelitis by suppressing IL-17 production and inhibits differentiation of Th17 cells. Acta Pharmacol Sin.
33. Wang GF#, Shi LP#, Ren YD#, Liu QF, Liu HF, Zhang RJ, Li Z, Zhu FH, He PL, Tang W, Tao PZ, Li C, Zhao WM, Zuo JP*. Anti-hepatitis B virus activity of chlorogenic acid, quinic acid and caffeic acid in vivo and in vitro. Antiviral Res
34. Garcia JM, Gao A, He PL, Choi J, Tang W, Bruzzone R, Schwartz O, Naya H, Nan FJ*, Li J*, Altmeyer R, Zuo JP*. High-throughput screening using pseudotyped lentiviral particles: A strategy for the identification of HIV-1 inhibitors in a cell-based assay. Antiviral Res.
35. Zhou R, Tang W, He PL, Yang YF, Li YC, Zuo JP*. (5R)-5-hydroxytriptolide inhibits the immune response of human peripheral blood mononuclear cells. Int Immunopharmacol.
